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In hepatocellular carcinoma, the combination of m6A inhibitors with sorafenib or lenvatinib reverses drug resistance ( 6.2 The SSP as a key metabolic pathway mediating resistance to conventional chemotherapy and targeted therapy The SSP serves as a pivotal metabolic pathway that mediates tumor resistance to conventional chemotherapeutic agents and targeted therapeutics

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Similar to corticosteroids, the results mostly show repigmentation in the face with moderate effects at other sites of the body

(6) Rapid tachyphylaxis: Continued tyramine exposure depletes releasable NE stores and replaces NE with pharmacologically weak false neurotransmitter stores, leading to diminished responsiveness despite ongoing tyramine presence