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This pathway primarily influences insulin secretion and glucagon inhibition in pancreatic beta and alpha cells, respectively

Diarrhea and constipation both occur, sometimes in the same individual at different points during treatment

[7] These medications have also been linked to improvements in blood pressure and cholesterol levels, enhancing overall metabolic health and potentially reducing the risk of heart failure and kidney disease

Postprandially secreted GIP and GLP-1 exert systemic metabolic control by a complex array of signaling mechanisms involving insulinotropic gut-pancreas and satiety-regulating gut-brain axes (4, 5)