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As larger and longer-term trials start to report their results, we will gain a clearer picture of whether GLP-1 agonists can ultimately modify disease progression or serve as mainly symptomatic therapies.

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A 2023 study in Diabetes Care found that GLP-1 receptor agonist users who maintained hydration while managing acute viral illness experienced fewer gastrointestinal complications than those who discontinued abruptly

Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on the plasma PAA to PAGN ratio