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Individuals who fall within one of those three weight classifications are at an increased risk of developing significant health problems, increasing their risk of developing: Various Types of Cancer, Diabetes, and Heart Disease (e.g., heart attack, stroke, etc.)

It oxidizes thiol groups of transcription factors, affecting their DNA binding ability and transcriptional activity, leading to changes in apoptosis-related gene expression

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J Int Soc Sports Nutr 14:18 Kristensen CA, Askenasy N, Jain RK et al (1999) Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31 P and 1 H magnetic resonance spectroscopic studies