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(2022) observed that although a two-month synbiotic intervention consisting of 510 9 CFU Lactobacillus acidophilus and Bifidobacterium longum and 60 mg of FOS in a double-blinded randomized controlled clinical trial involving hemodialysis patients with gastrointestinal complaints had a substantial effect in improving constipation and general quality of life in the synbiotic group, it did not reduce the levels of IS in their serum compared to the placebo group

The main drawbacks involve needle discomfort, potential injection site reactions, and the requirement for sterile technique

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Over the last decade and a half, several (injectable and most recent an oral) GLP-1 receptor agonist formulations have been introduced for the management of hyperglycemia in people with T2D [24]