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But they cant replace the effects of wrap around lifestyle medicine (resistance training, physical activity, supportive nutrition etc) Clinical data & real-world evidence confirm that fatigue is a common side effect of GLP-1 receptor agonists, affecting roughly 11% of patients in weight-management clinical trials (compared to 5% taking a placebo)

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National Heart, Lung, and Blood Institute

However, due to discrepancies in findings from clinical trials, real-world data, and fundamental research, definitive recommendations for diabetic retinopathy screening prior to GLP-1 RA treatment initiation remain elusive