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Emerging evidence indicates that distinct phosphorylation patterns, or barcodes, can influence GPCR engagement with -arrestins and determine signalling bias (9), potentially contributing to the disparity of pharmacological and therapeutic profiles observed among different GLP-1R agonists (10)

10.3390/ijms19030730 83 LeeY

Integrated development holds promise for deepening the understanding of lactations role in neurological disorders and guiding the design of rational therapeutic interventions based on pathological mechanisms

The study found no significant difference in overall efficacy between the two drugs at optimized doses [3]