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Furthermore, in aged mice treated with lipopolysaccharide to increase BBB permeability, melatonin-activated AMP-activated protein kinase in endothelial cells of the BBB [197], a kinase essential for maintaining BBB integrity [198]

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Case Study: Application of SSRIs in the Management of Generalized Anxiety Disorder Background : Samantha, a 32-year-old female marketing manager, presents to her primary care provider with complaints of persistent worry, difficulty concentrating, irritability, and frequent tension headaches