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Similar content being viewed by others Background Semaglutide is a glucagon-like peptide-1 receptor agonist that improves glycemic control and reduces cardiovascular outcomes in type 2 diabetes (T2D) by several mechanisms including enhanced cell response, postponed gastric emptying, inhibition of glucagon secretion, and weight-loss [1]

Interestingly, in another study, although F1 generation offspring did not develop obesity, both male and female F3 generation were obese and presented differential DNA methylation in genes associated with this comorbidity [123]

But weight regain isnt inevitableand there are strategies that can help reduce or even prevent it

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