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Oral use of the drug is possible thanks to co-formulation with sodium N-[8-(2-hydroxybenzoyl amino] caprylate (SNAC), which prevents digestion of the drug molecules in the gastrointestinal tract and facilitates absorption into circulation [143]

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Other contributing factors include: Small intestinal bacterial overgrowth (SIBO) Gastrointestinal infections or parasites Certain medicines that slow digestion (e.g., opioids, anticholinergics, tricyclic antidepressants, GLP-1 receptor agonists) Food intolerances or malabsorption disorders Swallowing excess air (aerophagia) Consumption of carbonated beverages Understanding the underlying cause is essential for effective management

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