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As a whole, cancer affects physiology homeostasis and the proper functioning of the organism [27]

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Interestingly, the Nrf2-mediated antioxidant response pathway is highly activated in FH-mutant cells (Ooi et al., 2011)

Despite this, in this review, we consider evidence from both therapeutic dosing and overdose studies because pre-clinical data suggest everyone would develop liver injury if the dose of paracetamol was sufficiently high for that individual

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