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For example, in the acoustic startle response and prepulse inhibition test, Lurcher mice show a similar startle response to WT mice, but are impaired in producing prepulse inhibition [170]

On a dose-for-dose basis, no

Given the high curing potential, very safe profile (lethal dose not achieved), and with a suitably wide effective range (g-ng regimens) and unlimited methods of application (i.e., intraperitoneal, intragastric, in drinking water or topically, at the site of injury) (for review, see [1,3,4,5,6,8,9,32,33,34])), it may be a real challenge for further therapy

Levenson JM, Schroeter S, Carroll JC, Cullen V, Asp E, Proschitsky M, Chung CH-Y, Gilead S, Nadeem M, Dodiya HB et al (2016) NPT088 reduces both amyloid- and tau pathologies in transgenic mice

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