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As our mechanistic understanding deepens and therapeutic applications broaden, GLP-1R agonists are poised to become cornerstone agents in the prevention and management of cardiometabolic diseases, ultimately improving patient outcomes and public health

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In vivo evaluation demonstrated that mice tolerated LAAM GSH-CQDs at doses up to 5000 mg kg 1 , compared to 18 mg kg 1 for LAAM TC-CQDs, 12 mg kg 1 for Lipo 2000, and 16 mg kg 1 for GO-CQDs

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The acetyltransferase p300 is recruited in trans to multiple enhancer sites by lncSmad7