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James OBrien, the condition may indicate an underlying life-threatening disease such as congestive heart failure, or it may be caused by something as benign as sitting for too long (OBrien 2005)

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That has helped shift the conversation from personal blame to medical management

However, clinical trials have shown that individuals may lose more weight with the 2.4 mg weekly dose of Wegovy than with the 3.75/23 mg daily dose of Qsymia after around a year of treatment