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A study evaluating the effectiveness of a 45-day VLEKT in improving acne in 31 young women with moderate acne and grade I obesity showed a reduction in markers of oxidative stress, such as reactive oxygen metabolite derivatives (dROMs), and a decrease in pro-inflammatory metabolites, including trimethylamine N-oxide (TMAO)

The activation of both TNFR1 and TNFR2 may induce c-Jun N-terminal kinase (JNK) [103] and the p38 MAPK pathways [104, 105]

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