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This on-demand model eliminates waste and reduces cold-chain logistics costs compared to mass-manufactured brand products

Despite that UPR helps cells to cope with ER stress, prolonged ER stress induces apoptotic cell death where the accumulation of unfolded protein in ER results in increased expression activating transcription factor 4 (ATF-4) that in turn increases the transcription of the proapoptotic protein, C/EPB-homologous protein-10 (CHOP-10) (Li et al., 2014)

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This work was supported by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia (Grants No