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Description

5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions

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The peptide enhances neutrophil chemotaxis while simultaneously promoting their apoptosis and clearance by macrophages, preventing the chronic inflammation that impairs healing

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doi:10.1038/234466a0

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DNA was sequenced from positive colonies containing the final product, pJB-GST-HTS-HS-GFP

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