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Inside the mitochondria, carnitine and acyl-CoA are then regenerated from the internalized acylcarnitines by CPTII before the acyl-CoA is catabolized in two-carbons units by oxidation by the mechanism described below with generation of acetyl-CoA as the main product in normal circumstances

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Iron-depletion-induced, PINK1/Parkin-independent mitochondrial autophagy is accompanied by lipid metabolic remodeling, with DGAT1-mediated lipid droplet biogenesis occurring prior to mitochondrial clearance

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