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However, under obese conditions, the number of nerve fibers within the AT appears to be drastically reduced, which not only leads one to ponder whether there is some association with ferroptosis

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Future therapeutic strategy for controlling NRF2-addicted cancers based on their metabolic features The dependency on glutamine and glutamate is regarded as an Achilles heel of NRF2-addicted cancer cells

In RA, arginine shifts energy metabolism from glycolysis to OXPHOS, thereby leading to metabolic reprogramming of osteoclasts and a bias toward M2 polarization, ultimately suppressing arthritis, blocking osteoclast formation, and preventing inflammatory bone loss and erosion (88)