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For example, a 2-month bundle includes 2.5 mg + 5 mg, and a 3-month bundle includes 2.5 mg + 5 mg + 7.5 mg
Any other effect can be considered as a pleiotropic, off-target effect, or in the case of unwanted actions, adverse effects ( Figure 1 )
Recent post hoc and exploratory subgroup analyses of trials with the GLP-1RAs liraglutide and dulaglutide and the SGLT-2is empagliflozin and dapagliflozin have examined this and have suggested that the CV benefits of these agents are observed independent of background metformin use [10,11,12,13]
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