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Each one of the naturally-occurring ingredients is shown to combat GI inflammation through distinct mechanisms, eliciting synergistic benefits

DOI: 10.1016/j.peptides.2005.01.029 Anti-Inflammatory Melanocortin Signalling Research using MT-2 as a pharmacological tool has investigated MC3R and MC4R-mediated anti-inflammatory pathways in macrophage, keratinocyte, and neuronal cell models, including NF-B pathway suppression, pro-inflammatory cytokine downregulation, and melanocortin-mediated immune modulation research areas of relevance to neuroinflammation and peripheral inflammatory signalling biology

Shergalis A, Bankhead A, Luesakul U, Muangsin N, Neamati N

1a for absolute quantification values