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Tumor Suppressor Activation Tumor suppressor activation represents particularly striking gene effects

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In the past, there has been controversy regarding the interaction of NFT with glutathione (Silva et al

Initially described as a pro-atherogenic molecule due to its proliferative role in VSMC, it was further demonstrated that the effect of IGF-I on VSMC was to compensate for local apoptosis, and that, overall, IGF-I is not pro-atherogenic in native arteries but anti-atherogenic[320], mainly through enhanced nitric oxide production[308]