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This complex gut microbiome contains both aerobic and anaerobic commensal microbes, but anaerobic microbes constitute 99% of the gut microbiota (Nagpal et al., 2017)

10.1038/s41467-020-19669-x 135 PengH.WuX.GeF.HuoZ.WenY.LiC.et al (2021)

Circulating small extracellular vesicle-encapsulated SEMA5A-IT1 attenuates myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass

To get a truer picture, they often check for high levels of methylmalonic acid (MMA) and homocysteine

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