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In comparisons between tirzepatide and semaglutide, when HbA 1c was measured in mmol/mol, all tirzepatide doses were comparable with semaglutide 2.0 mg and superior to semaglutide 1.0 mg and 0.5 mg (ESM Table 6)

it applies to a specific category of compounds where solubility is otherwise a documented problem, and its worth checking a compounds Certificate of Analysis before assuming its necessary

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You may have heard of insulin resistance or metabolic syndrome if you can't lose weight