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About the Experts Susie Reiner, Ph.D., is an exercise physiologist and founder of TheoryEx Performance, a scientific consulting agency

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Furthermore, investigations into comorbidities linked with hyperuricemia need expansion to better elucidate the role of transporter gene mutations in disease pathogenesis

Other causes of carnitine deficiency besides mutations in the SLC22A5 gene are classified as secondary carnitine deficiency and include other hereditary metabolic diseases (e.g., fatty acid oxidation defects), medication (valproic acid, cyclosporine, and pivampicillin), malnutrition, hemodialysis and renal tubular dysfunction (Fanconi nephropathy), and prematurity (lower placentary transfer)

doi: 10.1210/jc.2006-0587 102 YaoZGaoXLiuMChenZYangNJiaYMet al