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Neuromedin U- a new target in obesity

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GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors

doi: 10.1053/j.gastro.2013.04.006 [DOI] [PubMed] [Google Scholar] 61

During dose escalation, when your body is most vulnerable, minimizing these bladder irritants provides an additional layer of protection