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Morning timing aligns with the body's peak NAD+ synthesis window, which 5-Amino-1MQ modulates through NNMT suppression

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Benefits of B12 supplementation have been shown in a number of conditions, including diabetic neuropathy, back pain, mouth ulcers, autism spectrum disorder and elevated homocysteine levels, and it is generally considered to be very safe even at high dosages

If you already have a diagnosed deficiency under NHS care and your symptoms return before your next scheduled dose, that is a conversation to have with your GP, who can review the schedule