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Further Increase: If additional glycemic control is needed after at least 30 days on 7 mg, increase to 14 mg once daily

Libraries were prepared using KAPA Hyper Prep Kits for Illumina, (Kapa Biosystems) with SureSelect XT adaptors and primers (Agilent Technologies)

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Additionally, underlying conditions like hypothyroidism, PCOS, or medication interactions (certain antidepressants, steroids) can blunt semaglutide's effects even at optimal doses

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