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It has been studied for over 30 years, with a substantial body of preclinical research pointing to its regenerative and anti-inflammatory properties throughout the body, particularly in the gastrointestinal tract

More recently, hypertonic divalent salt aerosols with high alkalinity have been observed to provide therapeutic relief in the treatment of refractory chronic cough 86

Drug Deliv Transl Res 9

However, SPARC and MTPN, also identified in the EV proteomics analysis, were upregulated

This phenomenon, termed cellular senescence, defines the maximum number of cellular divisions, referred to as the Hayflick limit (27, 28)