It binds to toxins and metabolic byproducts, making them water-soluble so the body can flush them out
Mechanistically, by inhibiting HDAC activity, these agents augment histone acetylation levels (specifically H3 and H4), thereby activating the transcription of cardioprotective genes, including those regulating anti-apoptotic and antioxidant processes 152,155
One study (from 1999) mentions the issue described above, but it is not a credible source for the following reasons: The study wasn't performed on normal human proteins or healthy, intact skin (instead, a blend of animal and human proteins, and the pH relationship issue developed only when a fatty acid byproduct was added to the mix)
The company's terms of use reference a registered office in Brighton, Michigan
These combined effects alter stool consistency and frequency in the first 2 to 4 weeks of therapy