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Thus, despite the demonstrated senolytic effects of BCL-2 family inhibitors, their clinical translation is limited due to potential side effects, off-target effects on platelets and poor central nervous system (CNS) penetrance

Biomaterials 31 , 20342042 (2010)

Research category: Copper peptide / extracellular matrix research compound

GHK-Cu, delivered simultaneously to those same fibroblasts, amplifies the collagen signal while suppressing the excess inflammatory response

The active-site cavity, which is located between the two domains, comprises a glutathione binding site (G-site), formed mainly by the N-terminal domain, and a hydrophobic substrate-binding site (H-site), which is formed by the C-terminal domain