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In addition, GLP-1 can stimulate the epidermal growth factor (EGF), triggering the phosphatidylinositol-3 kinase (PI3K), which activates transcription factors associated with -cell growth while inhibiting those linked to -cell apoptosis (18)

The symptom typically appeared between weeks 2 and 8 of treatment and resolved within 412 weeks for most patients as homeostasis re-established

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Experimental and translational studies have suggested that GLP-1 drugs may improve endothelial function, nitric oxide signaling, oxidative stress and microvascular recruitment, they elaborated

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