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349,350,351,352 Although cargo uploading exogenously is simple and convenient to operate, the integrity of exosomes may be damaged during the loading process, which may affect the effect and require additional purification steps to remove the unloaded drugs

The results have been striking: GHK-Cu has been shown to modulate the expression of more than 4,000 human genes, with the net effect being a return toward expression patterns associated with younger, healthier tissue.6 The pathways most consistently affected include antioxidant defense (upregulation of catalase, superoxide dismutase, and glutathione synthesis), DNA damage repair, extracellular matrix remodeling, and anti-inflammatory signaling

doi: 10.1016/j.pharmthera.2021.108023 10

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Research Applications Tissue Repair & Regeneration BPC-157 and TB-500 accelerate fibroblast migration and angiogenesis, while GHK-Cu supports collagen remodeling, improving wound closure rates in animal studies [1]