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CONTRAVE is believed to work on the hypothalamus (appetite regulatory center) and dopamine reward system in the brain to regulate appetite

doi: 10.1016/j.pt.2018.07.011 21 GoldschlagerN.EpsteinA

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Phentermine remains widely prescribed by itself for short courses, and in 2012 it was FDA-approved in combination with topiramate for chronic weight management