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This answer is not clear, although it may be explained by the difference in kinetic and thermodynamic properties of selenols compared to thiols [35,36]

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If you raise the concentration of 5mTHF, that will increase the inhibition of GNMT, which will cause the concentration of SAM to go up

Concentration-wise, EGF is biologically active at very tiny amounts so finished products use it at low levels (think parts per million)