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Reasons for Weight Gain After Semaglutide While semaglutide is highly effective for weight loss, many patients see the pounds return after stopping the medication

Chronic stress keeps your body in a state of constant alert, never allowing your muscles to fully relax or stress hormones to return to baseline levels

This is the anatomical pattern that produces the characteristic "Ozempic face" appearance: hollow temples, flattened cheeks, deepened nasolabial folds, sunken under-eyes, and a more visible jawline edge that often reads as jowling

Studies have shown that Ozempic can effectively help with weight loss and improve blood sugar control for up to two years with few significant side effects

I weighed 218 pounds when I took my first Retatrutide dose in March 2025