Parikh S, Saneto R, Falk MJ, Anselm I, Cohen BH, Haas R, Medicine Society TM: A modern approach to the treatment of mitochondrial disease
when it ends, appetite returns (often stronger) The body defends against weight loss (an evolutionary survival mechanism) Lifestyle changes made while on medication may not be sustained without appetite suppression Metabolic rate decreases with weight loss, making it easy to regain if calorie intake increases Strategies to minimize regain (if you stop): Taper the dose gradually rather than stopping abruptly Transition to intensive behavioral support (counseling, nutrition coaching) Maintain calorie awareness and portion control habits developed on medication Prioritize protein intake and resistance exercise to preserve muscle mass Consider maintenance dose (lower dose to prevent regain, rather than full discontinuation) Accept that some regain is normal
Although none of the tested variants achieved statistical significance in this external dataset, differences in phenotype definition, allele frequencies, and cohort size may have reduced replication power
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Arcturus Therapeutics and Duke-NUS Medical School partner to develop a coronavirus (COVID-19) vaccine using STARR Technology
