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Hexosamine pathway overactivation Alters gene expression (e.g., PAI-1 and TGF-) promoting microvascular ischemia, oxidative stress, and neuronal apoptosis (78)

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El resultado es una prdida de visin sbita e indolora y, generalmente, irreversible

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However, for patients prescribed insulin at baseline, researchers still observed a significant benefit in CV risk reduction when assigned diabetes drugs, with an RR of 0.93 (95% CI, 0.88-0.98)