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Defective insulin signaling in adipocytes causes high rates of basal lipolysis and increased circulating levels of free fatty acids and glycerol, which leads to lipid accumulation at ectopic sites such as liver and muscle and interference with insulin signaling at those sites [24]
The impact of hypoxia on cytosolic NADP redox dynamics had remained less clear, since lack of oxygen as an electron sink causes metabolic reduction, but also boosts H 2 O 2 production and glutathione oxidation in different phases of the hypoxic episode [37]
A previous study reported significantly increased lipid peroxidation (measured by 4-HNE and MDA) in the synovial cells of OA than in RA patients and controls [46]
Healthy whole grains provide sustained energy, fibre, and nutrients for steady blood glucose
Weight loss itself also contributes to heart rate normalization, since excess body weight increases baseline cardiac demand
