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Methods Two sets of in silico experiments were performed using molecular docking simulations to determine the influence of hGH fragment 176191 peptide on the anticancer efficacy of doxorubicin 1) the binding affinities of hGH fragment 176191 peptide to the breast cancer receptors, 2) the effects of hGH fragment 176191 peptide binding on doxorubicin binding to these same receptors

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This ROS-driven cascade converges on microvascular dysfunctioncharacterized by dysregulated vasodilation, compromised endothelial barrier function, and increased vascular fragilityultimately manifesting as mucosal erosions and hemorrhage, the hallmark features of PHG [373]

IGF-1 Receptor Activation IGF-1 LR3 works by binding to IGF-1 receptors located on the surface of muscle and other tissue cells

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