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The challenge with an oral peptide is surviving the stomach, which is why the tablet pairs semaglutide with an absorption enhancer (SNAC) and comes with strict administration rules

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In preclinical models, chronic GLP-1 administration improves depression-like behaviors even in lean animals, an effect not mediated by weight loss

nonetheless, therapeutic concentrations seldom produce clinically meaningful inhibition of major drug-metabolizing pathways, and the agent lacks intrinsic estrogen-receptor agonism

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