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An immediate and then sustained effect on pressure in lower esophageal sphincter, and a postponed effect on pyloric sphincter after either 0.5 mg/kg or 1.0 mg/kg intraperitoneal challenge (white bars), pyloric sphincter seems to be less affected

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Water, saline, and common laboratory buffers

The drug also has adverse side effects such as diarrhea and vomiting, "but because these medications are titrated, meaning that the dose is increased gradually, we find a rate at which we can cease that side effect," according to Aronne