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4 r 4.9% ARR reported at 3 years in prespecified supplementary analysis

A phase I/II clinical trial found that the most common side effects were mild and transient (Teichman et al., 2006): Injection site reactions (redness, mild swelling) Headaches Flushing or warmth Temporary water retention Joint tightness or tingling Transient fatigue or dizziness Serious adverse events are rare when the peptide is used under medical supervision at appropriate doses

The phenotypic outcome is a shift toward higher energy expenditure and improved adipose/lipid profiles without the catabolic loss of lean tissue commonly seen with severe caloric restriction

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1997 Mar 01