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Typically, 2 mg of the RNA fraction was mixed with 200400 l of streptavidin agarose beads (Pierce) bound to 4 nmol of the biotinylated DNA probe (Supplementary Table 5) in 300 mM HEPESKOH (pH 7.0), 1.2 M NaCl, 15 mM EDTA and 1 mM DTT at 68 C for 30 min with shaking

193 These studies prove that PRMTs are potential targets for cancer therapy, and several PRMTs inhibitors are currently in clinical trials (Table 1)

The iron storage protein ferritin consists of ferritin light chain (FTL) and ferritin heavy chain 1 (FTH1) and functions to store iron in cells [59]

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