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However, in AD drug development, designing inhibitors with high selectivity poses significant challenges when faced with highly conserved or homologous binding pockets

The peptide's potent effects on growth factor signaling theoretically raise concerns about interactions with cancer biology, though no direct evidence supports this concern

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The well-defined safety profile and demonstrated radiosensitising effects of metformin highlights its potential repurposing as a strategy to boost response to radiation therapy in cancer