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At the intracellular signaling level, mitogen-activated protein kinases (MAPKs), including JNK and p38, have been identified as central transducers of inflammatory signaling [199]

Notably, recent studies found that Mn overexposure can also increase cellular Fe uptake, reduce antioxidant levels, resulting in increased lipid peroxidation and ferroptosis in both cells and mouse models (Wang et al., 2024)

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This calculation would suggest that GSH levels vary between all the steady state values ranging from 4,151 to 8,516 M Figure 3

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