Research overwhelmingly describes the safety of GHK-Cu positively, such as when the authors of a 2018 review called it a safe, inexpensive, extensively studied compound.14 However, even though copper peptides have demonstrated an impressive safety track record in studies, there are (as with most skin care actives) a few safety risks to consider
1996, 44.Zhai H., Leow Y.-H., Maibach H
Effects of tripeptide Gly-His-Lys in pain-induced aggressive-defensive behavior in rats
Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine
GHK-Cu is discussed here in the context of published research, clinical trials, and user-reported observations