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Coverage has expanded steadily since Wegovy's 2021 approval but remains uneven

doi: 10.1038/s41467-020-20790-0 11 KadlecAOBeyerAMAit-AissaKGuttermanDD

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A previous study has shown that despite reducing lipid oxidation, LA supplementation decreases hepatic fat content and the activity and mRNA expression levels of lipogenic enzymes (acetyl-CoA carboxylase [ACC], FAS, ATP-citrate lyase [ACLY], and PK) in the livers of rats fed a diet with 10% fat content, in which fish oil was replaced by vegetable oil to different proportions (20% and 100%), and another study (sesamin and LA) found the same