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The approval stems from the Phase IIIb SOUL trial involving over 9,600 patients, which showed MACE occurred in 12% of Rybelsus-treated patients versus 13.8% on placeboa statistically significant 14% treatment effect
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In 51 females and nine males having a body mass index (BMI) between 27 and 39 kg/m2, relationships between serum IGF-1, IGF-binding protein-3 (IGFBP-3), insulin, growth hormone (GH), blood glucose, and anthropometric measurements of body fat were examined
10.1016/S0140-6736(06)69705-5 8
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