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A Multicenter, Randomized, Double Blind, Placebo Controlled Phase II Study of PL 14736 Enema in the Treatment of Mild-To-Moderate Ulcerative Colitis

Hepatic event (HE) signals were evaluated using reporting odds ratios (ROR)

employed DNPH as a reactive matrix in MALDI-MS to detect peptides modified by 4-hydroxy-2-nonenal (HNE) in undigested samples, achieving the selective detection of modified peptides through the high D/I yield of hydrazone derivatives (Michael adducts with dinitrophenylhydrazine) (Figure )

The data from the previously described study illustrates the use of urine-based metabolomics technology for identifying metabolite characteristics and associated changes in metabolic pathways that characterize PD pathophysiology